Evidence of G.O.D.’s Miracle: Unearthing a RAG Transposon

G.O.D.'s Holy Grail: discovery of the RAG proteins.

Paleo-Immunology: Evidence Consistent with Insertion of a Primordial Herpes Virus-Like Element in the Origins of Acquired Immunity

BACKGROUND The RAG encoded proteins, RAG-1 and RAG-2 regulate site-specific recombination events in somatic immune B- and T-lymphocytes to generate the acquired immune repertoire. Catalytic activities of the RAG proteins are related to the recombinase functions of a pre-existing mobile DNA element in the DDE recombinase/RNAse H family, sometimes termed the "RAG transposon". METHODOLOGY/PRINCI...

Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

Co-option of RAG1 and RAG2 for antigen receptor gene assembly by V(D)J recombination was a crucial event in the evolution of jawed vertebrate adaptive immunity. RAG1/2 are proposed to have arisen from a transposable element, but definitive evidence for this is lacking. Here, we report the discovery of ProtoRAG, a DNA transposon family from lancelets, the most basal extant chordates. A typical P...

A Hidden Contributor to the Korean Miracle: The Korean Credit :union: Movement

Korean credit :::union:::s (CUs) are considered to be a hidden contributor to the “Korean miracle”, characterized by remarkable economic growth and relatively low income inequality. The Korean miracle not only generated wealth in an economically strapped and socially under-privileged people, but also contributed to regional community development and the democratization of Korean society. In...

Analysis of fold and fault-related fracture systems development using image logs at Asmari Formation in the Rag Sefid Anticline, SW Iran

Image logs of 13 wells in the Rag Sefid Anticline show two systems of fractures developed under two deformation phase in the Dezful Embayment. This deformation phases are folding resulted from Zagros NE contraction and reactivation of the basement fault rotated the fold axial trace within the Hendijan-Izeh fault zone. Folding phase comprises four sets of fractures, which include axial and cross...